

The scientist says the reason why Player's squad went berserk was because of a experimental nerve toxin to counter infantry. The Player saves a Scientist (the one from the beginning) in the facility and interrogates him. The Player guns them down and investigates an explosion on a nearby research facility. All of them were infected with some sort of virus and go berserk. The Player lands with part of the Strike Force, inculding the pilot and sniper named Jenkins, but something goes wrong. Unknown hostiles have boarded the plane, but the Strike Force takes them out regardless and at the end of the battle, parachute dramatically before the plane explodes. When leaving after the mission, their plane gets shot down. The story takes place in modern times and starts with a Strike Force squad putting down a rebellion in South America. The plot jumps to a flashback that will lead up to the events in the Facility.

The Commando has a few questions for the Scientist, setting in motion the central storyline. He is then saved by a Commando from the Strike Force Squad. He avoids some of the enemy forces but gets cornered and has to fight off some enemies. The opening of the game starts with a Scientist mixing some chemicals, when his facility is attacked by an unknown hostile force. They almost succeed, But the Strike Force Heroes intervene and save the day, and millions of lives. It is a story that involves a global terrorist cell called " Globex" that attempts to reduce opposing factions to mindless creatures of their will. Campaign is a game mode in Strike Force Heroes.
